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Dysplasia / Atypical hyperplasia

Definition – It is the disordered cellular development associated with metaplasia and hyperplasia caused by chronic irritation and prolonged inflammation. It is occur most commonly in epithelial cells.

Dysplasia characterised by cellular proliferation and cytologic changes as under…
  • Increase number of layers of epithelial cells.
  • Disorderly arrangement of cells from basal layer to the surface layer.
  • Loss of polarity i.e. nuclei lying away from basement membrane.
  • Cellular and nuclear pleomorphism.
  • Increase nucleocytoplasmic ratio.
  • Nuclear hyperchromatism.
  • Increase mitotic activity.

Most common examples of dysplastic changes are the uterine cervix and respiratory tract.

Metaplasia, dysplasia, adaptation , aasgaduli, pathology
Difference between Metaplasia and Dysplasia






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